Royal Air Force Typhoon fighter aircraft have operated alongside French aircraft in a combined operation on an subterranean weapons facility in Syria operated by the IS group, according to the UK's MoD.
The location, pinpointed through intelligence, was assessed as storing arms and explosives, the release indicated, and was situated in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our fighter planes employed precision-guided Paveway IV munitions to target a number of approach shafts leading to the site... early reports are that the objective was successfully hit," the ministry announced.
There was no indication of any civilian impact in the strike on Saturday evening and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - also known as the so-called Islamic State - established extremist governance over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This strike shows our UK leadership, and determination to work closely with our allies, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the Middle East," Britain's Defence Chief the minister stated.
RAF aircraft have carried out patrols over Syria to "prevent any attempted comeback" of IS following its routing at the Baghuz confrontation in 2019, the authorities noted.
"I want to thank every member of our armed forces involved in this operation for their expertise and their valour," the Defence Secretary said. "Including them were numerous UK service members on duty over Christmas and New Year. This action, to eliminate militants who endanger our security, highlights how UK forces are prepared to act, throughout the year, keeping Britain secure at home and powerful internationally."
During December, the United States armed forces conducted what it called a "large-scale strike" targeting Daesh sites in Syria, following an ambush claimed the lives of two American soldiers and a civilian linguist in Palmyra.
The United Nations reports IS still boasts an estimated 5,000 to 7,000 militants in both countries.